hpv25鍩哄洜鍨嬪垎鍨嬫娴嬭瘯鍓傜洅
2019-3-8
鍖荤枟鍣ㄦ娉ㄥ唽璇佺紪鍙凤細鍥芥娉ㄥ噯20173403364
路e6/e7 dna浣滈澏鐐癸紝閬垮厤婕忔 鐙锛?/span>鐙锛?/strong> 鐙锛?/strong>
路鏈€鍏ㄥ崄鍏涓珮鍗卞瀷锛岀簿鍑嗗垎鍨?/strong>
路鍗曠鍙嶅簲锛屽弻閲嶈川鎺э紝閬垮厤鍋囬槾鎬?/strong>
18绉嶄腑楂樺嵄鍨嬶細16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 73, 82
7绉嶄綆鍗卞瀷锛?/span>6, 11,42, 43, 44, 81, 83
e6/e7 dna浣滈澏鐐癸紝閬垮厤婕忔
hpv瀵艰嚧瀹鐥呭彉鐨勮繃绋嬪浘绀?/span>
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瀹鐧屾槸鐩墠鍞竴鐥呭洜鏄庣‘鐨勭檶鐥囷紝楂樺嵄鍨婬pv鎸佺画鎰熸煋浼氭渶缁堝鑷村棰堢檶鐨勫彂鐢?sup>[2]銆傚湪涓浗鎰熸煋楂樼骇鍒梾鍙樼殑濂?/span>鎬т汉缇や腑锛屾劅鏌撶巼鎺掑悕鍓嶅崄浣嶇殑hpv鍨嬪埆锛?6銆?2銆?8銆?8銆?3銆?1銆?1銆?3銆?8銆?9[3]銆侶pv妫€娴嬩腑杩涜鍨嬪埆鍖哄垎闈炲父鏈夊繀瑕?sup>[4]銆?/span>
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鈻?鍦ㄤ腑鍥芥劅鏌撻珮绾у埆鐥呭彉鐨勫コ鎬т汉缇や腑锛孒pv鍨嬪埆鐨勬劅鏌撶巼鎺掑簭[3]
鈻?hpv鍒嗗瀷妫€娴嬬殑鎰忎箟[4]
鍗曠鍙嶅簲锛屽弻閲嶈川鎺?/strong>
鈻?afa/鏂颁竴浠ｇ墖娈靛垎鏋愭妧鏈?/span>[5]
鈻?鎶€鏈?/strong>
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浜у搧鐗圭偣
路绮惧噯 鑷寸檶鍩哄洜e6/e7鍋氶澏鐐癸紝閬垮厤鍥燣1鍩哄洜涓㈠け閫犳垚鐨勬紡妫€ 18楂樺嵄鍨嬶紝鏈€鍏ㄦ娴嬶紝绮惧噯鍒嗗瀷锛屾棤浜ゅ弶鍙嶅簲 路鍙潬 dutp-ung閰堕槻姹℃煋浣撶郴锛岄伩鍏嶅亣闃虫€?/span> 鐙壒璁捐鐨勫弻閲嶈川鎺э紝閬垮厤鍋囬槾鎬?/span> 路渚挎嵎 鐪熸鍗曠澶氶噸鍙嶅簲浣撶郴锛屾娴嬮澏鐐规洿澶?/span> 鍙嶅簲浣撶郴閰嶅埗绠€鍗曪紝鎿嶄綔娴佺▼绠€渚匡紝杞欢鍒よ缁撴灉鍑嗙‘ |
妫€娴嬫祦绋?/strong>
鏍锋湰绫诲瀷锛氬棰堣劚钀界粏鑳炰繚瀛樻恫鏍锋湰銆乀ct鏍锋湰
閰嶅浠櫒锛?/span>
妫€娴嬬粨鏋滅ず鎰忓浘
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[1] woodman c b, collins s, young l s, et al. the natural history of cervical hpv infection: unresolved issues[j]. nature reviews cancer, 2007, 7(1): 11-22.
[2] walboomers j m, jacobs m v, manos m m, et al. human papillomavirus is a necessary cause of invasive cervical cancer worldwide.[j]. the journal of pathology,1999, 189(1): 12-19
[3] ico information centre on hpv and cancer, 2016
[4] 寤栫е骞筹紝璧靛仴 銆婁汉涔冲ご鐦ょ梾姣掑垎鍨嬫娴嬪湪涓村簥宸ヤ綔涓殑搴旂敤銆?涓浗瀹炵敤濡囩涓庝骇绉戞潅蹇? 2010 5锛?6锛?331-333
[5] zhang h, cheng h, wang q, et al. an advanced fragment analysis-based individualized subtype classification of pediatric acute lymphoblastic leukemia.[j].scientific reports, 2015.